Initially, 50 mg/day PO administered in 2 divided doses. Increase the daily dose by 50 mg once per week during weeks 2, 3, and 4. Increase the daily dose by 100 mg once per week during weeks 5 and 6; administer total daily dose in 2 divided doses. Making Sense of Antiepileptic Drugs in 2007 Thomas K. Koch, MD Ortho McNeil Pharmaceuticals Speakers Bureau Abbott Laboratories Speakers Bureau Topiramate, sold under the brand name Topamax among others, is a medication used to treat epilepsy and prevent migraines. It has also been used in alcohol dependence. For epilepsy this includes with generalized or focal seizures. It is taken by mouth. Effects of topiramate on other antiepileptic medicinal products. The addition of topiramate to other antiepileptic drugs (phenytoin, carbamazepine, valproic acid, phenobarbital, primidone) has no effect on their steady-state plasma concentrations, except in the occasional patient, where the addition of topiramate to phenytoin may result in an. TOPAMAX ® (topiramate) Tablets and Capsules. DESCRIPTION. Topiramate is a sulfamate-substituted monosaccharide. TOPAMAX ® (topiramate) Tablets are available as 25 mg, 50 mg, 100 mg, and 200 mg round tablets for oral administration. In situations where rapid withdrawal of topiramate is medically required, appropriate monitoring is recommended (see section 4.2). As with other AEDs, some patients may experience an increase in seizure frequency or the onset of new types of seizures with topiramate. Pediatric Patients 2 to 9 Years of Age. Dosing in patients 2 to 9 years of age is based on weight. During the titration period, the initial dose of Topiramate tablet is 25 mg/day nightly for the first week. Les tératogènes sont des agents pharmacologiques qui lors de leur utilisation provoquent le développement de masses cellulaires anormales au cours de la croissance fœtale, provoquant des défauts physiques sur le fœtus. Trokendi XR (topiramate) Extended-release Capsules. DESCRIPTION. Topiramate, USP, is a sulfamate-substituted monosaccharide. Trokendi XR™ (topiramate) extended-release capsules are available as 25 mg, 50 mg, 100 mg and 200 mg capsules for oral administration. Carbonic anhydrase inhibitor anticonvulsants inhibit the enzyme carbonic anhydrase. Generally carbonic anhydrase inhibitors are used to treat epilepsy, glaucoma, mountain sickness, and is used as a diuretic.